Acta anaesthesiologica Scandinavica
-
Acta Anaesthesiol Scand · Apr 2004
Comparative StudyDesflurane results in higher cerebral blood flow than sevoflurane or isoflurane at hypocapnia in pigs.
In clinical neuroanaesthesia, the increase in cerebral blood flow (CBF) and intracranial pressure caused by the cerebral vasodilative effects of an inhalational anaesthetic agent is counteracted by the cerebral vasoconstriction induced by hypocapnia. Desflurane and sevoflurane may have advantages over the more traditionally used isoflurane in neuroanaesthesia but their dose-dependent vasodilative effects at hypocapnia have not been compared in the same model using truly equipotent minimal alveolar concentrations (MACs). ⋯ More cerebral vasodilation at hypocapnia with high doses of desflurane than with sevoflurane or isoflurane indicates that desflurane might be less suitable for neuroanaesthesia than sevoflurane and isoflurane.
-
Acta Anaesthesiol Scand · Apr 2004
Biochemical markers for brain damage after carbon monoxide poisoning.
Carbon monoxide poisoning is associated with high mortality and a substantial risk for brain damage in survivors. Evidence for acute brain dysfunction may be obtained by measuring concentrations of suitable biochemical markers. We hypothesized that increased serum concentrations of Neuron-specific enolase (NSE) and S-100beta protein could be detected after carbon monoxide poisoning and that the concentration would correlate with the severity of intoxication. ⋯ Blood concentrations of NSE and S-100beta protein were not significantly increased after carbon monoxide poisoning and do not seem to be related to a history of unconsciousness.
-
Acta Anaesthesiol Scand · Apr 2004
Painful neuropathy alters the effect of gabapentin on sensory neuron excitability in rats.
Pain following peripheral nerve injury is associated with increased excitability of sensory neurons. Gabapentin (GBP), a novel anticonvulsant with an uncertain mechanism of action, is an effective treatment for neuropathic pain. We therefore investigated the effect of GBP on dorsal root ganglion (DRG) neurons from normal rats and those with painful peripheral nerve injury. ⋯ Nerve injury by CCI is associated with increased sensory neuron excitability, associated with a decreased AHP. In normal peripheral sensory neurons, GBP has pro-excitatory effects, whereas GBP decreases excitability in injured neurons, possibly on the basis of altered sodium channel function.
-
Acta Anaesthesiol Scand · Apr 2004
Clinical Trial Controlled Clinical TrialEffect of aminophylline on bispectral index.
The aim of the present study was to investigate the effects of aminophylline on BIS as well as clinical recovery in patients anesthetized with sevoflurane. ⋯ Recovery from sevoflurane anesthesia and BIS scores are improved in early period when aminophylline is given at emerging from anesthesia.
-
Acta Anaesthesiol Scand · Apr 2004
Development and validation of a brief, descriptive Danish pain questionnaire (BDDPQ).
A new pain questionnaire should be simple, be documented to have discriminative function, and be related to previously used questionnaires. ⋯ A Danish pain questionnaire that subjects and patients can self-administer has been developed and validated relative to the words used in the English McGill Pain questionnaire. The discriminative ability of the questionnaire among some common painful conditions has been tested and documented. The questionnaire may be of use in patient care and research.