Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Jul 2005
Randomized Controlled Trial Comparative Study Clinical TrialRandomized, double-blind study comparing postoperative effects of treatment timing with histamine H-receptor antagonist cimetidine.
The purpose of this study was to evaluate the effect of timing of preoperative, postoperative, and placebo administration of the H(2)-antagonist cimetidine on postoperative pain management and the incidence of side-effects. ⋯ Our results suggested that neither preoperative nor postoperative administration of cimetidine 4 mg kg(-1) provided a pre-emptive or preventive analgesic advantage for postoperative pain or morphine consumption, and that the use of cimetidine failed to reduce the incidence of nausea or vomiting.
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Acta Anaesthesiol Scand · Jul 2005
Randomized Controlled Trial Comparative Study Clinical TrialCerebral state index during anaesthetic induction: a comparative study with propofol or nitrous oxide.
Confidently predicting the depth of anaesthesia for the individual patient and independently of drug(s) type using EEG-based monitors has proven difficult. This open, randomized, explorative study of day surgical patients evaluates the ability of the Cerebral State Monitor (Danmeter AB, Odense, Denmark) of anaesthetic depth to identify loss of response (LOR) using either propofol or N(2)0 for induction. ⋯ The Cerebral State Index(trade mark) behaves as other depth of anaesthesia monitors with a progressive decrease during propofol induction but loss of consciousness with N(2)0 results in no change in CSI.
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Acta Anaesthesiol Scand · Jul 2005
Randomized Controlled Trial Comparative Study Clinical TrialPalmar skin conductance compared to a developed stress score and to noxious and awakening stimuli on patients in anaesthesia.
The number of fluctuations in the skin conductance per s (NFSC) as a measure of the sympathetic nervous system may be a tool for monitoring physiological stress during surgery and general anaesthesia. The purpose of this study was to find the sensitivity and specificity of the NFSC when compared to a peroperative clinical stress score. Moreover, different patterns of skin conductance responses were compared with the BIS score to find out if the mean level of skin conductance (SC) and NFSC monitoring could differentiate between awakening and noxious stimuli. ⋯ The NFSC is sensitive to clinical stress during surgical stimulation. Moreover, the combined use of SC and NFSC may have a potential to differentiate between situations of stress due to inadequate hypnotic effect vs. inadequate analgesic effect.
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Acta Anaesthesiol Scand · Jul 2005
Randomized Controlled Trial Clinical TrialEffects of ephedrine on intubating conditions following priming with rocuronium.
Onset of action of muscle relaxants is influenced by cardiac output and muscle blood flow. Ephedrine reduces the onset time of rocuronium. Onset is also shortened by priming. Accordingly, we hypothesized that priming combined with ephedrine is superior to either technique used separately. ⋯ Ephedrine in combination with propofol significantly improved clinical intubating conditions at 30 s following priming with rocuronium compared with priming with ephedrine without priming.
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Acta Anaesthesiol Scand · Jul 2005
Randomized Controlled Trial Clinical TrialXenon anaesthesia may preserve cardiovascular function in patients with heart failure.
The hypothesis that xenon anaesthesia provided haemodynamic stability was tested in patients with heart failure in a prospective, randomized, single-blind design. ⋯ With propofol, MAP is reduced and LVEF is not increased in spite of reduced afterload. In contrast, MAP and LVEF are maintained with xenon.