Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Oct 2008
Correlation between central venous oxygen saturation and oxygen delivery changes following fluid therapy.
The rationale for using central venous oxygen saturation (ScvO(2)) in various clinical scenarios is that it reflects the balance between oxygen delivery (DO(2)) and demands. In this study, we evaluated the correlation between ScvO(2) and DO(2) changes (Delta Do(2), DeltaScvO(2)) in patients receiving fluid therapy following coronary surgery. We also correlated the changes of mean arterial pressure (Delta MAP) and central venous pressure (Delta CVP), with Delta DO(2). ⋯ A significant correlation between ScvO(2) and DO(2) changes was found in patients receiving fluid therapy following coronary surgery. ScvO(2) could be used as an indicator to track DO(2) and to guide volume loading.
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Acta Anaesthesiol Scand · Oct 2008
Early time course of altered leukocyte response to lipopolysaccharide and peptidoglycan in porcine gunshot injury.
Penetrating injuries are frequently combined with polybacterial soiling. Clearance of the microorganisms depends on the ability to activate immune responses, but post-traumatic hyporeactivity of immune cells is almost universal. The aim of this study was to map the early time course of this altered leukocyte reactivity, and to compare the reactions to subsequent Gram-positive or Gram-negative challenges. ⋯ Trauma almost instantaneously reprogrammed circulating leukocytes. As measured with TNF-alpha, a profound hyporeactivity to LPS, but not to PepG, was induced. In addition, no global down-regulation of leukocyte function was found after stimulation with LPS.