Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Feb 2012
Critically ill cancer patients in the intensive care unit: short-term outcome and 1-year mortality.
The short-term survival of critically ill patients with cancer has improved over time. Studies providing long-term outcome for these patients are scarce. ⋯ Organ failure scores on day 7 can predict outcome for cancer patients in the ICU. Viral infection and reactivation appear to worsen the prognosis. One-year mortality rate is high and depends on the malignancy.
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Acta Anaesthesiol Scand · Feb 2012
Review Meta AnalysisQuality of pharmacokinetic studies in critically ill patients receiving continuous renal replacement therapy.
Continuous renal replacement therapy (CRRT) is the preferred renal replacement therapy modality in the critically ill. We aimed to reveal the literature on the pharmacokinetic studies in critically ill patients receiving CRRT with special reference to quality assessment of these studies and the CRRT dose. We conducted a systematic review by searching the MEDLINE, EMBASE, and the Cochrane databases to December 2009 and bibliographies of relevant review articles. ⋯ The median (IQR) weighted CRRT dose was 23.7 (18.8-27.9) ml/kg/h. More attention should be paid both to standardizing the CRRT dose and reporting of the CRRT parameters in pharmacokinetic studies. The general quality of the studies during CRRT in the critically ill was only moderate and would be greatly improved by reports in concordant with the ADQI recommendations.
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Acta Anaesthesiol Scand · Feb 2012
The effects of age on maintenance of intense neuromuscular block with rocuronium.
Increasing age is associated with a longer duration of action of neuromuscular block. The aim of this study was to determine the influence of ageing on the recovery of the post-tetanic count (PTC) from rocuronium-induced neuromuscular block. ⋯ The times from rocuronium injection to reappearance of the first response to PTC stimulation are approximately twofold longer and more variable in older than younger patients. Hence, the dosing interval of rocuronium should be adjusted using neuromuscular monitoring when maintaining intense neuromuscular block, especially in older patients.
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Acta Anaesthesiol Scand · Feb 2012
Feasibility of cerebral near-infrared spectroscopy monitoring in the pre-hospital environment.
Traumatic brain injury (TBI) is a significant cause of death and severe disability from trauma. Pre-hospital care of patients with TBI may be aided by non-invasive monitoring of cerebral tissue oxygenation. This pilot observational study was designed to assess if cerebral tissue oximetry using near-infrared spectroscopy (NIRS) is feasible in the pre-hospital and transport environment. ⋯ NIRS monitoring is feasible in the pre-hospital environment, opening up the possibility for further research of the role of this modality in this setting.