Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · May 2012
Parecoxib mitigates spatial memory impairment induced by sevoflurane anesthesia in aged rats.
Inflammation in brain plays a critical role in the pathogenesis of cognitive impairment. Anti-inflammatory therapy may thus constitute a novel approach for associated cognitive dysfunction. The present study investigated the effects of parecoxib in the prevention of cognitive impairments induced by sevoflurane in aged rats. ⋯ Parecoxib mitigates spatial memory impairment induced by sevoflurane anesthesia in aged rats. The synaptic morphometry change may be one of the mechanisms involved in learning and memory deficit.
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Acta Anaesthesiol Scand · May 2012
The Peptic Ulcer Perforation (PULP) score: a predictor of mortality following peptic ulcer perforation. A cohort study.
Accurate and early identification of high-risk surgical patients with perforated peptic ulcer (PPU) is important for triage and risk stratification. The objective of the present study was to develop a new and improved clinical rule to predict mortality in patients following surgical treatment for PPU. ⋯ The PULP score accurately predicts 30-day mortality in patients operated for PPU and can assist in risk stratification and triage.
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Acta Anaesthesiol Scand · May 2012
Recombinant factor VIIa as last-resort treatment of desperate haemorrhage.
Studies are inconclusive regarding clinical outcomes after administration of recombinant activated coagulation factor VII (rFVIIa) during severe haemorrhage. The circumstances encountered during desperate haemorrhage make it difficult to include the most critically ill patients that could possibly benefit the most from such treatment into randomized controlled trials. We report our experience with rFVIIa as last-resort treatment of desperate haemorrhage when all standard treatment has failed. ⋯ The majority of unselected consecutive patients receiving rFVIIa as last-resort treatment for desperate haemorrhage were considered to have immediate clinical response as well as reduced transfusion requirements and correction of coagulation parameters. An immediate clinical response to rFVIIa may possibly be predictive of survival.
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Acta Anaesthesiol Scand · May 2012
Retraction Of PublicationRetraction. Spinal 2-chloroprocaine: effective dose for ambulatory surgery.