Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Aug 2012
Meta AnalysisBayesian enhanced meta-analysis of post-operative analgesic efficacy of additives for caudal analgesia in children.
The authors calculated the effect size for post-operative analgesia of three additives, clonidine, neostigmine, and tramadol to bupivacaine, ropivacaine, or levobupivacaine used for single-dose caudal extradural blockade in children. ⋯ Neostigmine provides the longest post-operative analgesia. With clonidine, the duration of analgesia is shorter and sedation is increased, but the probability for PONV could be decreased.
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Acta Anaesthesiol Scand · Aug 2012
Randomized Controlled Trial Comparative StudyNon-steroidal anti-inflammatory drugs reduce the stress response during sevoflurane anesthesia.
Non-steroidal anti-inflammatory drugs are analgesics commonly used for post-operative pain. However, their effect on dosages of inhaled anesthetics during surgery is unclear. We investigated the effect of flurbiprofen axetil and parecoxib sodium on the minimum alveolar concentration of sevoflurane required to blunt stress responses to skin incision under general anesthesia. ⋯ The non-steroidal anti-inflammatory drugs flurbiprofen axetil and parecoxib sodium decreased the minimum alveolar concentration of sevoflurane required to blunt the stress response to skin incision during general anesthesia.
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Acta Anaesthesiol Scand · Aug 2012
Pleural effusion decreases left ventricular pre-load and causes haemodynamic compromise: an experimental porcine study.
Although pleural effusion is a common complication in critically ill patients, detailed knowledge is missing about the haemodynamic impact and the underlining mechanisms. The aim of this study was to evaluate the haemodynamic effect of incremental pleural effusion by means of invasive haemodynamic parameters and transthoracic echocardiography. ⋯ Incremental volumes of unilateral pleural effusion induced a significant haemodynamic impact fully reversible after drainage. Pleural effusion causes a significant decrease of left ventricular pre-load in a diverse picture of haemodynamic compromise.