Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Aug 2012
Effects of propofol with hyperthermia in a rat model of endotoxemic shock.
We aimed to investigate the effects of active mild hyperthermia and the effects of active mild hyperthermia with propofol on mortality and inflammatory responses during endotoxin-induced shock in rats. ⋯ The mortality rates in the present study were extremely high; further hypotension and elevations in plasma pro-inflammatory and anti-inflammatory cytokine concentrations after endotoxin injection were not attenuated by mild hyperthermia between 39 °C and 40 °C, but they were attenuated by propofol with mild hyperthermia.
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Acta Anaesthesiol Scand · Aug 2012
Clinical TrialA newly developed scavenging system for administration of nitrous oxide during labour: safe occupational use.
Nitrous oxide (N(2) O) is routinely used as an analgesic in obstetrics during labour. Epidemiological studies have linked chronic occupational exposure to N(2) O to specific health problems, including reproductive risks. Occupational exposure limits (OELs) allow the use of N(2) O once appropriate preventive and safety measures have been taken. We assessed the effectiveness of a scavenger system (Anevac P-system®, Medicvent Heinen & Löwestein Benelux, Barneveld, the Netherlands) applied in N(2) O administration during labour in a midwifery-led birthing centre in the Netherlands. ⋯ The Anevac P-scavenging system during N(2) O analgesia in labour prevents exceeding OELs in professional workers. The scavenging system appeared acceptable and effective, and can be considered in hospital settings that use N(2) O as analgesic during labour.