Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Sep 2013
Failure to protect against myocardial ischemia-reperfusion injury with sevoflurane postconditioning in old rats in vivo.
Sevoflurane post-conditioning (SpostC) protects young hearts against ischemia-reperfusion injury. It is unknown whether the infarct-limiting effect is also maintained in aged cohorts and whether there are age-associated differences in the underlying mechanisms. ⋯ SpostC-mediated cardioprotection in young rats is not effective in senescent rats, which may at least be the consequence of failure to activate Akt and ERK1/2, and resultant failure to inhibit mPTP opening.
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Acta Anaesthesiol Scand · Sep 2013
Improved neuroprotective effect of methylene blue with hypothermia after porcine cardiac arrest.
Induced mild hypothermia and administration of methylene blue (MB) have proved to have neuroprotective effects in cardiopulmonary resuscitation (CPR); however, induction of hypothermia takes time. We set out to determine if MB administered during CPR could add to the histologic neuroprotective effect of hypothermia. ⋯ Administration of MB during CPR added to the short term neuroprotective effects of induced mild hypothermia induced 30 min after ROSC.
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Acta Anaesthesiol Scand · Sep 2013
Randomized Controlled TrialPropofol-remifentanil or sevoflurane for children undergoing magnetic resonance imaging? A randomised study.
Magnetic resonance imaging (MRI) of children is generally performed under sedation or with general anaesthesia (GA), but the ideal regimen has not been found. The aim of this study was to see if propofol-remifentanil would be a suitable alternative for the maintenance of anaesthesia in this category of patients. ⋯ The PR infusion ensured a satisfactory stay in the recovery room, but additional boluses were necessary during the MRI. Sevoflurane was reliable during the MRI, but emergence delirium was a concern.
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Acta Anaesthesiol Scand · Sep 2013
Randomized Controlled Trial Clinical TrialImpact of Bispectral Index for monitoring propofol remifentanil anaesthesia. A randomised clinical trial.
Previous research has shown that the use of the bispectral index (BIS) monitor to measure the depth of anaesthesia reduces the amount of anaesthetics administered and the recovery time from general anaesthesia. The effect of BIS on recovery from anaesthesia and consumption of anaesthetics in a paediatric population receiving total intravenous anaesthesia (TIVA) with propofol and remifentanil has not been studied. ⋯ BIS monitoring for guidance of propofol-remifentanil anaesthesia does not result in reduced consumption of anaesthetics and does not reduce time to extubation in adult and children compared with conventional practice.