Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Feb 2014
Randomized Controlled Trial Comparative StudyIntrathecal chloroprocaine vs. lidocaine in day-case surgery: recovery, discharge and effect of pre-hydration on micturition.
Spinal chloroprocaine may be more suitable for day-case surgery than lignocaine because of faster block resolution and time to discharge.
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Acta Anaesthesiol Scand · Feb 2014
ReviewPopulation pharmacometrics in support of analgesics studies.
Population pharmacometric modeling is used to explain both population trends as well as the sources and magnitude of variability in pharmacokinetic and pharmacodynamics data; the later, in part, by taking into account patient characteristics such as weight, age, renal function and genetics. The approach is best known for its ability to analyze sparse data, i.e. when only a few measurements have been collected from each subject, but other benefits include its flexibility and the potential to construct more detailed models than those used in the traditional individual curve fitting approach. ⋯ In addition, the use of these models to design and optimize future studies is discussed. In this context, finding the best design factors, such as the sampling times or the dose, for future studies within pre-defined criteria using a previously constructed population pharmacokinetic model can help researchers acquire clinically meaningful data without wasting resources and unnecessarily exposing vulnerable patient groups to study drugs and additional blood sampling.
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Acta Anaesthesiol Scand · Feb 2014
Multicenter StudyAssessment of early cognitive recovery after surgery using the Post-operative Quality of Recovery Scale.
Cognitive problems early after surgery are often considered transient in nature. Neuropsychological performance and its relation to other recovery parameters have rarely been systematically assessed during this period. ⋯ Failure of cognitive recovery is reasonably common 3 days after surgery, can fluctuate and is associated with poorer early recovery in the activities of daily living, nociceptive and physiological domains.
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Acta Anaesthesiol Scand · Feb 2014
Observational StudyMinimal impairment in pulmonary function following laparoscopic surgery.
Pulmonary function may be impaired in connection with laparoscopic surgery, especially in the head-down body position, but the clinical importance has not been assessed in detail. The aim of this study was to assess pulmonary function after laparoscopic hysterectomy and laparoscopic cholecystectomy. We hypothesised that arterial oxygenation would be more impaired after hysterectomy performed in the head-down position than after cholecystectomy in the head-up position. ⋯ Minimal impairment in pulmonary gas exchange was found after laparoscopic surgery. Pulmonary shunt was larger after laparoscopic cholecystectomy, but no clinically significant differences in postoperative pulmonary gas exchange or spirometry were found between laparoscopic hysterectomy and laparoscopic cholecystectomy.
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Acta Anaesthesiol Scand · Feb 2014
Case ReportsA prehospital use of ITClamp for haemostatic control and fixation of a chest tube.
We here present three cases in which a new device, the ITClamp Hemorrhage Control System (Innovative Trauma Care, Inc., Edmonton, Canada), was used for bleeding control and for securing a chest tube.