Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Aug 2016
CommentZero expiratory pressure and low oxygen concentration promote heterogeneity of regional ventilation and lung densities.
It is not well known what is the main mechanism causing lung heterogeneity in healthy lungs under mechanical ventilation. We aimed to investigate the mechanisms causing heterogeneity of regional ventilation and parenchymal densities in healthy lungs under anesthesia and mechanical ventilation. ⋯ ZEEP together with low FI O2 promoted heterogeneity of ventilation and lung tissue densities, fostering a greater amount of airway closure and ventilation inhomogeneities in poorly aerated regions.