Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Aug 2022
Randomized Controlled TrialKinetics of 5% and 20% albumin: a controlled crossover trial in volunteers.
Albumin for intravenous infusion is marketed in two concentrations, 20% and 5%, but how they compare with regard to plasma volume expansion over time is unclear. ⋯ The most important difference between the fluids was a dehydrating effect of 20% albumin when the same albumin mass was administered.
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Acta Anaesthesiol Scand · Aug 2022
Randomized Controlled TrialRocuronium 0.3 mg/kg or 0.9 mg/kg comparing onset time, duration of action and intubating conditions in patients 80 years and older. A randomized study.
Limited data exist about the optimal dose of rocuronium for intubation in elderly patients. We hypothesized that rocuronium 0.9 mg/kg would lead to a shorter onset time than 0.3 mg/kg in patients above 80 years. ⋯ Rocuronium 0.9 mg/kg resulted in a shorter onset time compared to rocuronium 0.3 mg/kg in patients above 80 years of age. In 66% of the patients receiving rocuronium 0.3 mg/kg a TOF count of 0 was not obtained.
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Acta Anaesthesiol Scand · Aug 2022
Observational StudyEpidural Analgesia and Postoperative Complications in Colorectal Cancer Surgery. An Observational Registry-based Study.
In colorectal cancer, surgical resection is fundamental for curative treatment. Epidural analgesia mitigates the perioperative physiologic stress response caused by surgery, and reduction in perioperative stress may reduce postoperative complications. Nevertheless, epidural analgesia also causes hypotension and lower limb motor weakness that can impair postoperative recovery. Here, we aimed to assess the association between epidural analgesia and postoperative complications after colorectal cancer surgery. ⋯ In total, in this observational study based on Danish registries, we found no association between epidural analgesia and postoperative complications after colorectal cancer surgery.
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Acta Anaesthesiol Scand · Aug 2022
Pupil response to painful stimuli during inhalation anaesthesia without opioids in children.
Pupil dilation reflex measured by a pupillometer is known to be a useful parameter for assessing the response to perioperative noxious stimuli. In children, pupillometer can reflect changes after painful stimuli during anaesthesia or guide anaesthesia to reduce opioid consumption. However, to date, there are no data regarding pupil response during inhalation anaesthesia with analgesia by intravenous acetaminophen in children. ⋯ We suggest dilation of the pupil and decrease in NPi can indicate response to noxious stimuli in children. Regardless of sufficiency of analgesia, pupil dilation and decrease in NPi were observed after skin incision in children under general anaesthesia with 1 MAC of sevoflurane and intravenous acetaminophen.
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Acta Anaesthesiol Scand · Aug 2022
Clinical TrialSerum concentration of oral midazolam as pediatric preanesthetic medication and factors related to sedation level.
Preanesthetic medication is important to eliminate surgical anxiety in pediatric patients and facilitate their smooth transfer to the operating room. Midazolam is the most commonly used preanesthetic medication. However, it has been reported that the sedative effect varies from patient to patient. In this study, the pharmacokinetics of midazolam were examined, and the aim was to assess the factors affecting the quality of sedation. ⋯ Clinical trial registry: UMIN R000052504.