Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Aug 2017
Randomized Controlled Trial Multicenter StudyFactors associated with early extubation after superior cavopulmonary connection: analysis from single ventricle reconstruction trial.
To evaluate the landscape of early extubation, and identify factors associated with early extubation (≤ 24 h) after superior cavopulmonary connection (stage 2 operation) among children with single ventricle anatomy. ⋯ Data from this large multicenter study demonstrate that approximately one-half of the patients undergoing operation for superior cavopulmonary connection are extubated within 24 h after heart operation. Furthermore, early extubation is associated with shorter hospital length of stay.
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Acta Anaesthesiol Scand · Aug 2017
Randomized Controlled Trial Multicenter StudyStress ulcer prophylaxis in the intensive care unit trial: detailed statistical analysis plan.
In this statistical analysis plan, we aim to provide details of the pre-defined statistical analyses of the Stress Ulcer Prophylaxis in the Intensive Care Unit (SUP-ICU) trial. The aim of the SUP-ICU trial is to assess benefits and harms of stress ulcer prophylaxis with a proton pump inhibitor in adult patients in the intensive care unit (ICU). ⋯ Stress ulcer prophylaxis is standard of care in ICUs worldwide, but has never been tested in large high-quality randomised placebo-controlled trials. The SUP-ICU trial will provide important high-quality data on the balance between the benefits and harms of stress ulcer prophylaxis in adult critically ill patients.
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Acta Anaesthesiol Scand · Jul 2017
Multicenter Study Observational StudyTrace elements in patients on continuous renal replacement therapy.
Intensive care patients with acute kidney injury (AKI), treated with continuous renal replacement therapy (CRRT) are at great risk for disturbances in plasma levels of trace elements due to the underlying illness, AKI, and dialysis. This study was performed to increase our knowledge regarding eight different trace elements during CRRT. ⋯ The low levels of selenium and rubidium in blood and plasma from CRRT patients, together with the loss via CRRT effluent, raises the possibility of the need for selenium supplementation in this group of patients, despite the unchanged levels during the short study period. Further investigations on the effect of additional administration of trace elements to CRRT patients would be of interest.
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Acta Anaesthesiol Scand · Apr 2017
Randomized Controlled Trial Multicenter StudyEffects of fluid restriction on measures of circulatory efficacy in adults with septic shock.
The haemodynamic consequences of fluid resuscitation in septic shock have not been fully elucidated. Therefore, we assessed circulatory effects in the first 24 h of restriction of resuscitation fluid as compared to standard care in intensive care unit (ICU) patients with septic shock. ⋯ We observed no indications of worsening of measures of circulatory efficacy in the first 24 h of restriction of resuscitation fluid as compared with standard care in adults with septic shock who had received initial resuscitation.
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Acta Anaesthesiol Scand · Mar 2017
Multicenter StudyPain prevalence in hospitalized children: a prospective cross-sectional survey in four Danish university hospitals.
Pain management in hospitalized children is often inadequate. The prevalence and main sources of pain in Danish university hospitals is unknown. ⋯ This study reveals high pain prevalence in children across all age groups admitted to four Danish university hospitals. The majority of children in moderate to severe pain did not have a documented pain assessment, and evidence-based pharmacological and/or integrative ('non-pharmacological') measures were not systematically administered to prevent or treat pain. Thus, practice changes are needed.