Acta anaesthesiologica Scandinavica
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Acta Anaesthesiol Scand · Oct 2002
Multicenter StudyVentilator treatment in the Nordic countries. A multicenter survey.
A 1-day point prevalence study was performed in the Nordic countries to identify ventilator-treatment strategies in the region. ⋯ The vast majority of patients were ventilated with pressure-regulated modes. Tidal volume was well below what has been considered conventional in recent large trials. Correlations between the parameters of gas exchange, respiratory mechanics, ventilator settings and physiological status of the patients was poor. It appears that blood gas values are the main tool used to steer ventilator treatment. These results may help to design future interventional studies of ventilator treatment.
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Acta Anaesthesiol Scand · Apr 2002
Randomized Controlled Trial Multicenter Study Comparative Study Clinical TrialDouble-blind comparison of the variability in spontaneous recovery of cisatracurium- and vecuronium-induced neuromuscular block in adult and elderly patients.
This study was designed to compare variability in the offset of two neuromuscular blocking agents with different elimination pathways. ⋯ Whereas both the clinically effective duration and the duration of SSR are comparable between the adult and the elderly patients receiving cisatracurium, they differ substantially between these two age groups for vecuronium. Furthermore, the variability in offset is significantly lower in patients receiving cisatracurium, especially in the elderly, which may be of particular clinical interest.
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Acta Anaesthesiol Scand · Mar 2002
Randomized Controlled Trial Multicenter Study Comparative Study Clinical TrialRemifentanil sedation compared with propofol during regional anaesthesia.
The short onset and offset of remifentanil may allow for accurate dosing of sedative effect with few side-effects and rapid recovery. In this study remifentanil is compared with propofol for sedation during successful regional anaesthetic blocks. ⋯ Propofol results in less respiratory depression and nausea when sedation is needed during a case with a successful regional block. Remifentanil may be considered as an alternative if pain during the procedure is a major concern or if amnesia is contraindicated.
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Acta Anaesthesiol Scand · Nov 2001
Randomized Controlled Trial Multicenter Study Clinical TrialPlasma concentrations of ropivacaine following a single-shot caudal block of 1, 2 or 3 mg/kg in children.
For documenting the properties of ropivacaine used for regional anaesthesia in children, the relationship between dose and resulting systemic exposure is essential. The aim of this pharmacokinetic part of a randomised, multicentre, double-blind study was to determine the free and total plasma levels of ropivacaine in children aged between 4 and 12 years following a single-shot caudal dose of 1, 2 or 3 mg/kg of ropivacaine for postoperative pain management. ⋯ Following single-shot caudal doses of 1-3 mg/kg in children up to 25 kg and aged between 4 and 12 years, plasma levels of free ropivacaine increase in proportion to dose and all were shown to be within safe limits.
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Acta Anaesthesiol Scand · Aug 2000
Randomized Controlled Trial Multicenter Study Comparative Study Clinical TrialA comparison of anaesthesia using remifentanil combined with either isoflurane, enflurane or propofol in patients undergoing gynaecological laparoscopy, varicose vein or arthroscopic surgery.
Anaesthesia comprising remifentanil plus isoflurane, enflurane or propofol was randomly evaluated in 285, 285 and 284 patients, respectively, undergoing short-procedure surgery. ⋯ Anaesthesia combining remifentanil with volatile hypnotics or TIVA with propofol was effective and well tolerated. Times of extubation, postanaesthesia recovery and recovery room discharge were rapid, consistent and similar for all three regimens.