Journal of paediatrics and child health
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J Paediatr Child Health · Dec 1998
Randomized Controlled Trial Comparative Study Clinical TrialRandomised trial of histoacryl blue tissue adhesive glue versus suturing in the repair of paediatric lacerations.
To compare histoacryl blue tissue adhesive glue with suturing in the repair of simple paediatric lacerations. ⋯ Tissue adhesive glue is faster and probably less painful than suturing. Tissue adhesive glue has the same cosmetic result as suturing when used for the repair of simple lacerations in children.
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J Paediatr Child Health · Oct 1998
Randomized Controlled Trial Comparative Study Clinical TrialRelative bioavailability and plasma paracetamol profiles of Panadol suppositories in children.
To determine the relative bioavailability and plasma paracetamol concentration profiles following administration of a proprietary formulation of paracetamol suppositories to postoperative children. ⋯ Absorption of paracetamol following rectal administration of Panadol suppositories to postoperative children is slower and reduced as compared to oral therapy. The hard wax and liquid filled products have similar absorption characteristics. The usually quoted antipyretic therapeutic range for paracetamol is 10-20 mg/L, although 5 mg/L may be effective. A single rectal dose of 25 mg/kg will obtain this lower concentration within 1 h of administration and maintain it for up to 6 h. When given in an appropriate dose for analgesia, maximum plasma paracetamol concentrations would be available in the immediate postoperative period if the rectal dose was given 2 h before the planned end of the procedure.
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J Paediatr Child Health · Dec 1995
Randomized Controlled Trial Clinical TrialAnalgesia for venepuncture in a paediatric surgery centre.
To establish an effective and efficient method of painless venepuncture in children 8 years and older in an ambulatory paediatric surgery centre. ⋯ Oral midazolam in combination with 50% nitrous oxide provides adequate analgesia and anxiolysis for venepuncture in patients 8 years and older. The addition of EMLA cream or intradermal lidocaine will decrease the likelihood of patient movement.
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J Paediatr Child Health · Jun 1995
Randomized Controlled Trial Clinical TrialMorphine increases synchronous ventilation in preterm infants.
To examine the short-term cardiorespiratory effects of intravenous morphine infusion in ventilated preterm infants. ⋯ Intravenous morphine infusion increases synchronicity of spontaneous and ventilator-delivered breaths in preterm infants. Morphine reduces heart rate and respiratory rate without reducing blood pressure, and may help to reduce duration of oxygen therapy in preterm infants with hyaline membrane disease.
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J Paediatr Child Health · Feb 1994
Randomized Controlled Trial Comparative Study Clinical TrialAerosol deposition in cystic fibrosis using an aerosol conservation device and a conventional jet nebulizer.
The deposition of technetium radiolabelled aerosol within the lungs of 12 stable cystic fibrosis patients (mean age 12.7 years) was compared using the Acorn nebulizer and mouthpiece alone, and the Acorn nebulizer attached to the Mizer Aerosol Conservation Device (MACD). The total activity delivered to the patient using the MACD was 11.1% (+/- 7.8% s.d.) of the initial dose, compared to 5.8% (+/- 4.2% s.d.) with the nebulizer and mouthpiece alone (P < 0.05). ⋯ No significant correlation was found between aerosol deposition and pulmonary function. The Mizer Aerosol Conservation Device significantly increases both total intrapulmonary aerosol deposition and peripheral aerosol distribution.