Annals of oncology : official journal of the European Society for Medical Oncology
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Randomized Controlled Trial
Efficacy of venlafaxine for the prevention and relief of oxaliplatin-induced acute neurotoxicity: results of EFFOX, a randomized, double-blind, placebo-controlled phase III trial.
Oxaliplatin neurosensory toxicity is dose limiting and may present as acute symptoms and/or cumulative peripheral neuropathy. ⋯ Venlafaxine has clinical activity against oxaliplatin-induced acute neurosensory toxicity.