Neurosurgery clinics of North America
The most recent articles from:
Neurosurg. Clin. N. Am.
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Neurosurg. Clin. N. Am. · Oct 2011
Multicenter Study Clinical TrialResponsive neurostimulation suppresses synchronized cortical rhythms in patients with epilepsy.
Deep brain stimulation (DBS) is an established treatment for Parkinson's disease, and is increasingly used for other neuropsychiatric conditions including epilepsy. Nevertheless, neural mechanisms for DBS and other forms of neurostimulation remain elusive. ⋯ Neurostimulation acutely suppressed gamma frequency (35-100 Hz) phase-locking. This may represent a therapeutic mechanism by which responsive neurostimulation can suppress epileptiform activity and disconnect stimulated regions from downstream targets in epilepsy and other neuropsychiatric conditions.