Journal of cardiovascular electrophysiology
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J. Cardiovasc. Electrophysiol. · May 2012
Randomized Controlled Trial Multicenter StudyCelivarone for maintenance of sinus rhythm and conversion of atrial fibrillation/flutter.
Celivarone, a new noniodinated benzofuran derivative pharmacologically related to dronedarone and amiodarone, has been shown to have antiarrhythmic properties at a molecular level. The purpose of the 2 trials presented here (MAIA and CORYFEE) was to assess celivarone efficacy in the maintenance of sinus rhythm postcardioversion and for the conversion of atrial fibrillation (AF)/atrial flutter (AFL). ⋯ In these studies, celivarone does not appear to be efficacious in the maintenance of sinus rhythm in AF/AFL patients or for the conversion of AF/AFL patients.