Archives of orthopaedic and trauma surgery
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Arch Orthop Trauma Surg · Jan 1999
Randomized Controlled Trial Clinical TrialEffects of recombinant human erythropoietin on thrombosis and fibrinolysis in autologous transfusion for hip surgery.
Recombinant human erythropoietin (rHuEPO) is effective in allowing autologous blood donation in patients unable to donate because of anemia. As adverse effects of rHuEPO might include activation of coagulation and possibly fibrinolysis, we investigated these possibilities in the context of autologous blood donation preceding hip surgery. ⋯ Coagulation and fibrinolysis were increased significantly by intraoperative blood loss in both groups, but not by rHuEPO. Coagulation and fibrinolysis were not activated by rHuEPO for elective hip surgery.