Acta neurologica Scandinavica
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Acta Neurol. Scand. · Feb 2021
Meta AnalysisCannabidiol in conjunction with clobazam: analysis of four randomized controlled trials.
To assess the efficacy and safety profile of add-on cannabidiol (CBD) in patients with Lennox-Gastaut syndrome (LGS) and Dravet syndrome (DS) on clobazam and in the overall population of four randomized, controlled phase 3 trials. ⋯ Add-on CBD was effective in reducing seizures in the overall populations and in conjunction with clobazam. Somnolence and sedation occurred more frequently in patients on CBD and clobazam.