Behavioural pharmacology
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Behavioural pharmacology · Nov 2003
Comparative StudyFacilitation and disruption of memory for the passive avoidance task in the day-old chick using dopamine D1 receptor compounds.
This series of studies provides a behavioural account of dopamine D1-receptor-dependent facilitation and disruption of memory for the single-trial passive avoidance task in the day-old chick. The D1 antagonist, SCH23390, induced memory disruption in a dose-dependent manner from 60 min after training with a strong (100% methyl anthranilate) aversant experience. ⋯ The D2 antagonist, sulpiride, and the D2 agonist, quinpirole, showed no memory effects. The research indicates an important role for dopamine D1-dependent mechanisms in memory formation in the chick.