The Journal of steroid biochemistry and molecular biology
-
J. Steroid Biochem. Mol. Biol. · Sep 2014
Multicenter Study Observational StudySerum lipoprotein composition and vitamin D metabolite levels in clinically isolated syndromes: Results from a multi-center study.
High serum cholesterol is adversely associated with clinical and imaging disease progression outcomes in multiple sclerosis (MS) and in clinically isolated syndrome (CIS), the earliest stage of MS. Low vitamin D levels are associated with an increased risk of disease progression. ⋯ The associations between cholesterol biomarkers and vitamin D metabolite levels in CIS are consistent with the biochemical inter-dependence between the two pathways. Cholesterol biomarkers should be considered for inclusion as covariates when assessing vitamin D levels in CIS.