Acta obstetricia et gynecologica Scandinavica
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Acta Obstet Gynecol Scand · Jul 2011
Review Meta AnalysisRepeated antenatal corticosteroid treatment: a systematic review and meta-analysis.
To systematically review the efficacy and safety of repeated antenatal corticosteroid on neonatal morbidity, growth and later development. ⋯ Repeated corticosteroid treatment decreased the risk of respiratory distress syndrome among preterm infants. Weekly or biweekly repeated betamethasone restricted intrauterine growth, which raises concerns about long-term consequences on neurodevelopment and metabolism. More follow-up studies are needed to confirm the long-term safety of repeated betamethasone.