Acta psychiatrica Scandinavica
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Acta Psychiatr Scand · Mar 2012
Evidence that interactive effects of COMT and MTHFR moderate psychotic response to environmental stress.
A functional interaction between Catechol-O-Methyltransferase (COMT) Val158Met and methylenetetrahydrofolate reductase (MTHFR) C677T has been shown to differentially affect cognition in patients with schizophrenia and healthy controls; the effect of COMT Val158Met × MTHFR interaction on resilience to stress in patients and controls remains to be examined. ⋯ Stress reactivity associated with COMT Val158Met in patients with psychosis may crucially depend on MTHFR C677T genotype.