Journal of magnetic resonance imaging : JMRI
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J Magn Reson Imaging · Oct 2007
Absolute quantification of cerebral blood flow in normal volunteers: correlation between Xe-133 SPECT and dynamic susceptibility contrast MRI.
To compare absolute cerebral blood flow (CBF) estimates obtained by dynamic susceptibility contrast MRI (DSC-MRI) and Xe-133 SPECT. ⋯ A reasonable positive linear correlation between MRI-based and SPECT-based CBF estimates was observed after AIF time-integral correction. The use of DSC-MRI typically results in overestimated absolute perfusion estimates and the present study indicates that this trend is further enhanced by the use of high magnetic field strength (3T).
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J Magn Reson Imaging · Oct 2007
High-resolution T1 mapping of the brain at 3T with driven equilibrium single pulse observation of T1 with high-speed incorporation of RF field inhomogeneities (DESPOT1-HIFI).
To investigate an alternative approach to correct for flip angle inaccuracies in the driven equilibrium single pulse observation of T1 (DESPOT1) T1 mapping method. ⋯ The described approach, dubbed DESPOT1-HIFI, permits whole-brain T1 mapping at 3T, with 1 mm(3) isotropic voxels, in a clinically feasible time (approximately 10 minutes) with T1 accuracy greater than 5% and with high precision.
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J Magn Reson Imaging · Oct 2007
Quantification of rodent cerebral blood flow (CBF) in normal and high flow states using pulsed arterial spin labeling magnetic resonance imaging.
To implement a pulsed arterial spin labeling (ASL) technique in rats that accounts for cerebral blood flow (CBF) quantification errors due to arterial transit times (dt)-the time that tagged blood takes to reach the imaging slice-and outflow of the tag. ⋯ Even when flow is accelerated, CBF can be accurately determined using pulsed ASL, as long as dt and outflow of the tag are accounted for.
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J Magn Reson Imaging · Oct 2007
Interleaved water and fat imaging and applications to lipid quantitation using the gradient reversal technique.
To implement and evaluate the gradient reversal-based chemical shift imaging technique to obtain qualitative and quantitative spatially-registered fat and water images with high imaging efficiency at very high field. ⋯ The proposed MRI technique permits interleaved water and fat imaging, with which spectrally well-separated water and fat images at the identical slice locations could be obtained in a single acquisition without increasing scan time. The technique could be used for in vivo quantitative mapping of lipid content and applied to investigations using small animal experiment models.