International journal of paediatric dentistry
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Int J Paediatr Dent · Jul 2012
Randomized Controlled Trial Comparative StudyOptimising the dose of oral midazolam sedation for dental procedures in children: a prospective, randomised, and controlled study.
Midazolam sedation poses a significant dilemma in paediatric dentistry, which is to find out the optimal dosing with minimal undesirable adverse events. In this study, we aimed to compare the effect of three doses of oral midazolam (0.5, 0.75, and 1 mg/kg) on the sedative state and cooperative behaviour of children during dental treatment. We further compared completion rates, parent satisfaction, and all adverse events. ⋯ Amount of 0.75 mg/kg oral midazolam appears to be the optimal oral dose in terms of effectiveness, acceptability, and safety for dental treatments in paediatric patients, when administered by an experienced, paediatric anaesthetist.