Journal of cardiothoracic and vascular anesthesia
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J. Cardiothorac. Vasc. Anesth. · Dec 1995
Randomized Controlled Trial Comparative Study Clinical TrialEffects of a paf-receptor antagonist on hemodynamics during and after cardiopulmonary bypass.
To assess after cardiopulmonary bypass (CPB) the role of paf-acether (paf), a phospholipid mediator whose injection in animal mimics the hemodynamics observed after CPB. ⋯ Because the inotropic and vasodilator therapy and the volume loading were the same between groups, this study suggests that pretreatment with a paf-receptor antagonist improves post-CPB pulmonary resistance. Nevertheless, this beneficial effect is transient without consequences on left ventricular function indices.
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J. Cardiothorac. Vasc. Anesth. · Dec 1995
Comparative StudyThe relationship between systolic pressure and stroke volume describes myocardial contractility.
To develop a method of measuring end-systolic elastance from information obtained outside the ventricle and thereby simplify its transduction. ⋯ In this study, measurement of EES from the ventricular outflow tract during progressive aortic constriction produced results more consistent and descriptive than EES by traditional techniques and has the potential for obtaining elastance measurements from possibly less invasive techniques.
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J. Cardiothorac. Vasc. Anesth. · Dec 1995
Cerebral complications after cardiac surgery assessed by S-100 and NSE levels in blood.
Assessment of the value of blood analysis of the astroglia protein, S-100, and neuron-specific enolase for the detection of nervous system dysfunction after cardiac surgery. ⋯ S-100 and neuron-specific enolase levels after cardiac surgery are associated with neurologic complications. The results have implications on patient-related treatment and prognosis as well as for the development of safer perfusion techniques.
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J. Cardiothorac. Vasc. Anesth. · Dec 1995
Effects of hypothermic cardiopulmonary bypass on the pharmacodynamics and pharmacokinetics of rocuronium.
To study the influence of hypothermic cardiopulmonary bypass (CPB) on the pharmacodynamics and pharmacokinetics of rocuronium. ⋯ Hypothermic CPB prolongs the duration of action of maintenance doses and alters the plasma concentration-response relationship of rocuronium. These changes may be the result of, on the one hand, an increased sensitivity of the neuromuscular transmission and/or decreased muscle contractility and, on the other hand, the result of a reduced plasma clearance during hypothermia.
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J. Cardiothorac. Vasc. Anesth. · Dec 1995
Comparative StudyClinical estimation of left and right ventricular volume with open chest compared with transesophageal echocardiography and fast-response thermodilution.
A clinical measure--inspection of the relation of the heart (acute margin) to the diaphragm--has shown a strong positive correlation to transesophageal echocardiographic (TEE) determination of left ventricular end-diastolic area (LVEDA) during weaning from cardiopulmonary bypass (CPB). The present study examines the correlation between right ventricular end-diastolic volumes (RVEDV) before and after CPB when using the same clinical measure of left ventricular dimension. ⋯ It is concluded that there is only a weak correlation regarding RVEDV before and after CPB when the patient is transfused to the line of contact, whereas this clinical measure correlates well with LVEDA.