Journal of biopharmaceutical statistics
-
A useful testing strategy in phase III trials: combined test of superiority and test of equivalence.
A useful testing strategy is proposed for a confirmatory phase III clinical trial. It consists of a combined test of superiority and test of equivalence, and it is easy to apply. ⋯ It is shown that the procedure needs no adjustment for multiplicity from the point of view of the closed testing procedure. The relationship between this strategy and a confidence interval is also discussed.