American heart journal
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American heart journal · Oct 2001
Randomized Controlled Trial Comparative Study Clinical TrialRegression of left ventricular remodeling in chronic heart failure: Comparative and combined effects of captopril and carvedilol.
This study evaluated the independent and combined effects of captopril and carvedilol on left ventricular remodeling in chronic heart failure. Although angiotensin-converting enzyme inhibitors and b-blockers are known to attenuate the remodeling process in chronic heart failure, a direct comparison of these agents has not been performed. ⋯ Although angiotensin-converting enzyme inhibitor therapy did not alter left ventricular volume, treatment with carvedilol was associated with reductions in chamber volume; both drugs reduced left ventricular mass and sphericity. These beneficial effects on remodeling may help to explain the relative prognostic benefits of these therapies.