The Annals of pharmacotherapy
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Randomized Controlled Trial
Comparative pharmacokinetics and pharmacodynamics of doripenem and meropenem in obese patients.
Antimicrobial pharmacokinetic and pharmacodynamic data are limited in obesity. ⋯ Doripenem and meropenem pharmacokinetics differ in obesity. However, currently approved dosing regimens provide adequate pharmacodynamic exposures for susceptible bacteria in obese patients.