Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
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Randomized Controlled Trial Clinical Trial
A prospective intervention study on higher-dose oseltamivir treatment in adults hospitalized with influenza a and B infections.
It is unclear if higher-dose oseltamivir provides benefit beyond the standard dose in influenza patients who require hospitalization. ⋯ ClinicalTrials.gov, NCT01052961.
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Variant influenza virus infections are rare but may have pandemic potential if person-to-person transmission is efficient. We describe the epidemiology of a multistate outbreak of an influenza A(H3N2) variant virus (H3N2v) first identified in 2011. ⋯ In a large outbreak of variant influenza, the majority of infected persons reported exposures, suggesting that swine contact at an agricultural fair was a risk for H3N2v infection. We identified limited person-to-person H3N2v virus transmission, but found no evidence of efficient or sustained person-to-person transmission. Fair managers and attendees should be aware of the risk of swine-to-human transmission of influenza viruses in these settings.
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Multicenter Study
Clinical features and outcomes in patients with disseminated toxoplasmosis admitted to intensive care: a multicenter study.
Characteristics and outcomes of adult patients with disseminated toxoplasmosis admitted to the intensive care unit (ICU) have rarely been described. ⋯ Severe disseminated toxoplasmosis leading to ICU admission has a poor prognosis. Recipients of allogeneic hematopoietic stem cell transplant appear to have the highest risk of mortality. We identified systolic cardiac dysfunction as a major determinant of outcome. Strategies aimed at preventing this fatal opportunistic infection may improve outcomes.
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Observational Study
Clinical characteristics of Dengue shock syndrome in Vietnamese children: a 10-year prospective study in a single hospital.
Dengue shock syndrome (DSS) is a severe manifestation of dengue virus infection that particularly affects children and young adults. Despite its increasing global importance, there are no prospective studies describing the clinical characteristics, management, or outcomes of DSS. ⋯ With prompt intervention and assiduous clinical care by experienced staff, the outcome of this potentially fatal condition can be excellent.