Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
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Randomized Controlled Trial Clinical Trial
A prospective intervention study on higher-dose oseltamivir treatment in adults hospitalized with influenza a and B infections.
It is unclear if higher-dose oseltamivir provides benefit beyond the standard dose in influenza patients who require hospitalization. ⋯ ClinicalTrials.gov, NCT01052961.
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The introduction of the Haemophilus influenzae serotype b (Hib) conjugate vaccine into national immunization has led to rapid and sustained declines in invasive Hib disease incidence across all age groups. In industrialized countries with established Hib vaccination programs, however, little is known about individuals who develop invasive Hib disease. This study describes the epidemiology of invasive Hib disease in England and Wales during 2000-2012 and the clinical characteristics of laboratory-confirmed Hib cases diagnosed during 2009-2012. ⋯ Control of Hib disease in England and Wales is currently the best that has been achieved since the introduction of routine Hib vaccination in 1992. Invasive Hib disease is no longer a major cause of acute bacterial meningitis in children but, instead, cases are more likely to present as pneumonia in older adults with comorbidities, similar to the less virulent nonencapsulated H. influenzae.
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Multicenter Study
Clinical features and outcomes in patients with disseminated toxoplasmosis admitted to intensive care: a multicenter study.
Characteristics and outcomes of adult patients with disseminated toxoplasmosis admitted to the intensive care unit (ICU) have rarely been described. ⋯ Severe disseminated toxoplasmosis leading to ICU admission has a poor prognosis. Recipients of allogeneic hematopoietic stem cell transplant appear to have the highest risk of mortality. We identified systolic cardiac dysfunction as a major determinant of outcome. Strategies aimed at preventing this fatal opportunistic infection may improve outcomes.
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Observational Study
Clinical characteristics of Dengue shock syndrome in Vietnamese children: a 10-year prospective study in a single hospital.
Dengue shock syndrome (DSS) is a severe manifestation of dengue virus infection that particularly affects children and young adults. Despite its increasing global importance, there are no prospective studies describing the clinical characteristics, management, or outcomes of DSS. ⋯ With prompt intervention and assiduous clinical care by experienced staff, the outcome of this potentially fatal condition can be excellent.