Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
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Multicenter Study
Influence of virulence genotype and resistance profile in the mortality of Pseudomonas aeruginosa bloodstream infections.
The type III secretion system (TTSS) is a major virulence determinant of Pseudomonas aeruginosa. The objective of this study was to determine whether the TTSS genotype is a useful prognostic marker of P. aeruginosa bacteremia mortality. We also studied the potential association between TTSS genotypes and multidrug-resistant (MDR) profiles, and how this interaction impacts the outcome of bloodstream infections. ⋯ Our results indicate that the exoU genotype, which is associated with specific susceptibility profiles, is a relevant independent marker of early mortality in P. aeruginosa bacteremia.