Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
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Recent population-based cohort studies have questioned the role of pneumococci as the most frequent pathogen causing severe infection in patients after splenectomy. The aim of the study was to define the causative pathogens and clinical presentation of patients with overwhelming postsplenectomy infection (OPSI). ⋯ Pneumococcal infections remain the most important cause of severe sepsis and septic shock following splenectomy.