Dermatology : international journal for clinical and investigative dermatology
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Dermatology (Basel) · Jan 1996
Review Case ReportsLivedo-like dermatitis (Nicolau's syndrome): a review of three cases.
We report 3 patients with typical features of livedo-like dermatitis. Emergency vasoactive therapy was administered to 2 of these patients, in whom the lesions healed completely. Although spontaneous resolution cannot be ruled out, we think that early recognition of this entity leading to rapid vasoactive treatment may limit the extent of thrombotic complications and the resulting tissue necrosis.
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Dermatology (Basel) · Jan 1996
Randomized Controlled Trial Clinical TrialDouble-blind crossover study of high-dose cetirizine in cholinergic urticaria.
Cholinergic urticaria does not respond well to treatment with conventional antihistamines and is difficult to study because of its highly variable clinical expression which depends on the presence of eliciting factors. ⋯ These data show a high efficacy of cetirizine at twice its normally recommended dose which may be related to the specific antiallergic effects of this newer-generation antihistamine.
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Dermatology (Basel) · Jan 1996
Review Case ReportsPrurigo pigmentosa, ketonemia and diabetes mellitus.
The etiology of prurigo pigmentosa still remains unknown. We present a 16-year-old female patient with ketonemia caused by diabetes mellitus. The eruption subsided when blood glucose and total ketone levels were controlled by subcutaneous insulin injection. We propose that ketonemia caused by diabetes mellitus may play a role in the pathogenesis of prurigo pigmentosa.
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Dermatology (Basel) · Jan 1996
Comparative StudyTachyphylaxis to histamine-induced wheal suppression by topical 0.05% clobetasol propionate in normal versus croton oil-induced dermatitic skin.
Patients often tell about reduced effectiveness of topical steroids on repeated use. Tachyphylaxis to these agents has been demonstrated in humans for vasoconstriction and histamine-induced wheal suppression in normal skin, but not in diseased skin. Relevance of these data to diseased skin is not clear. Further, the clinical impression does not appear to match tachyphylaxis shown in normal skin with regard to the time course. ⋯ Time courses of tachyphylaxis to the action of 0.05% clobetasol propionate were significantly different in normal skin and dermatitic skin. Complete tolerance occurred earlier in dermatitic skin compared to normal skin.
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Dermatology (Basel) · Jan 1996
Clinical and pathophysiological aspects of hydroxyethyl starch-induced pruritus: evaluation of 96 cases.
It has been recently recognized that long-term infusions of hydroxyethyl starch (HES) as a substitute of human plasma may lead to deposits within the human skin and clinically induces severe pruritus in approximately one-third of the patients treated. ⋯ Our findings indicate that pruritus in HES-infused patients is most likely not triggered by pruritogenic mediators. We support data from the recent literature, suggesting a direct stimulation of cutaneous nerves by HES deposits. In patients suffering from long-standing itching it seems important to consider previous HES exposure as a possible cause not only in generalized pruritus but also in localized symptoms.