Internal medicine
-
Randomized Controlled Trial Comparative Study Clinical Trial
Lispro is superior to regular insulin in transient intensive insulin therapy in type 2 diabetes.
The optimal approach to relatively recent onset type 2 diabetes patients is still unknown. We speculated that the use of short-acting insulin analogs might be of particular benefit in this context. ⋯ Two-week intensive insulin therapy with lispro appeared to be more effective than that with regular insulin in type 2 diabetes in attaining both more rapid beta-cell rest and greater suppression of glucagon. These changes may provide significant long-term benefits.