American journal of surgery
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Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial
Combination tramadol plus acetaminophen for postsurgical pain.
This multicenter, randomized, double-blind, active- and placebo-controlled trial evaluated tramadol plus acetaminophen (APAP) for orthopedic (n = 153) and abdominal (n = 152) postsurgical pain. ⋯ Tramadol plus APAP (mean dose 4.4 tablets) was effective and well tolerated for postsurgical pain and showed better tolerability than did codeine plus APAP.