American journal of surgery
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Mutations in BRCA1 or BRCA2 genes results in an elevated risk for developing both breast and ovarian cancers over the lifetime of affected carriers. General surgeons may be faced with questions about surgical risk reduction and survival benefit of prophylactic surgery. ⋯ Clinical management of patients at increased risk for breast cancer requires consideration of risk, patient preference, and quality of life.
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Mutations in BRCA1 or BRCA2 genes results in an elevated risk for developing both breast and ovarian cancers over the lifetime of affected carriers. General surgeons may be faced with questions about surgical risk reduction and survival benefit of prophylactic surgery. ⋯ Clinical management of patients at increased risk for breast cancer requires consideration of risk, patient preference, and quality of life.