Paediatric anaesthesia
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Paediatric anaesthesia · Oct 2002
Randomized Controlled Trial Clinical TrialSpinal versus peripheral effects of adjunct clonidine: comparison of the analgesic effect of a ropivacaine-clonidine mixture when administered as a caudal or ilioinguinal-iliohypogastric nerve blockade for inguinal surgery in children.
The adjunctive use of clonidine to local anaesthetics has been reported to enhance analgesia both after spinal and peripheral administration. However, no attempt has been made to compare spinal and peripheral application of clonidine in the same surgical context in order to further explore the mechanism for the analgesic action of clonidine when administered together with local anaesthetics. ⋯ This pilot study demonstrates a trend for better postoperative analgesia following peripheral administration of clonidine compared with central application. However, the main mechanism for the adjunct analgesic effect of clonidine when administered together with local anaesthetics requires further study.
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Paediatric anaesthesia · Oct 2002
Randomized Controlled Trial Comparative Study Clinical TrialPremedication with midazolam in young children: a comparison of four routes of administration.
We undertook a study to determine the effects of four routes of administation on the efficacy of midazolam for premedication. ⋯ Intranasal, oral, rectal and sublingual midazolam produces good levels of sedation and anxiolysis. Mask acceptance for inhalation induction was easy in the majority of children, irrespective of the route of drug administration.
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Paediatric anaesthesia · Oct 2002
Randomized Controlled Trial Comparative Study Clinical TrialA comparison of two different doses of ketamine with midazolam and midazolam alone as oral preanaesthetic medication on recovery after sevoflurane anaesthesia in children.
This investigation prospectively evaluated the effect of oral premedication of two different doses of ketamine with midazolam and midazolam alone on the recovery of children after sevoflurane anaesthesia. ⋯ The combination of midazolam and ketamine as oral preanaesthetic medication did not significantly affect the recovery time of children after sevoflurane anaesthesia.
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Paediatric anaesthesia · Oct 2002
Randomized Controlled Trial Clinical TrialPreemptive diclofenac reduces morphine use after remifentanil-based anaesthesia for tonsillectomy.
We investigated the effect of preincisional rectal diclofenac on pain scores and postoperative morphine requirements of children undergoing tonsillectomy after remifentanil-propofol anaesthesia in a randomized clinical trial. ⋯ Preemptive diclofenac given rectally reduced pain intensity and morphine requirements of children anaesthetized with remifentanil for tonsillectomy.
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Paediatric anaesthesia · Oct 2002
Randomized Controlled Trial Clinical TrialUnconscious sedation in children: a prospective multi-arm clinical trial.
We report the evaluation of six sedative-hypnotic and analgesic combinations administered to children undergoing brief periods of unconscious (or deep) sedation for painful procedures. ⋯ The combination of methohexital and remifentanil appears to be a satisfactory method for unconcious sedation for short painful procedures in children.