Paediatric anaesthesia
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Paediatric anaesthesia · Jun 2011
Exploring the pharmacokinetics of oral ketamine in children undergoing burns procedures.
The aim of this study was to describe ketamine pharmacokinetics when administered orally to children suffering from burn injury in >10% body surface area. ⋯ The ketamine pharmacokinetics in children with minor burns are similar to those without burns. The peak ratio of norketamine/ketamine at 1 h is 2.8 after oral administration allowing an analgesic contribution from the metabolite at this time. There is low relative bioavailability (<0.5) and slow variable absorption. Dose simulation in a child (3.5 years, 15 kg) suggests a dose regimen of oral ketamine 10 mg·kg(-1) followed by intravenous ketamine 1 mg·kg(-1) i.v. with the advent of short-duration surgical dressing change at 45 min.
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Paediatric anaesthesia · Jun 2011
Review Meta AnalysisKetamine for perioperative pain management in children: a meta-analysis of published studies.
Balanced analgesia, using both opioid and nonopioids agents, has become the standard care for postoperative pain management. Ketamine, a compound with analgesic and antihyperalgesic properties, has been shown to decrease postoperative pain and opioid requirements in adults. The goal of the present meta-analysis was to investigate postoperative analgesic properties of ketamine in pediatric patients. ⋯ This meta-analysis found that administration of ketamine was associated with decreased PACU postoperative pain intensity and nonopioid analgesic requirement. However, ketamine failed to exhibit a postoperative opioid-sparing effect.
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The prevalence of childhood obesity is increasing. The focus of this review is the special anesthetic considerations regarding the perioperative management of obese children. With obesity the risk of comorbidity such as asthma, obstructive sleep apnea, hypertension, and diabetes increases. ⋯ This has important implications on how to estimate the optimal drug dose. This article offers a review of the literature on definition, prevalence and the pathophysiology of childhood obesity and provides suggestions on preanesthetic evaluation, airway management and dosage of the anesthetic drugs in these patients. The authors highlight the need of supplemental studies on various areas of the subject.
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Paediatric anaesthesia · Jun 2011
Randomized Controlled Trial Comparative StudyCrossover comparison of airway sealing pressures of 1.5 and 2 size LMA-ProSeal™ and LMA-Classic™ in children, measured with the manometric stability test.
To compare airway sealing pressures, air leak, optimal positioning of the LMA-ProSeal™ and LMA-Classic™ in children. ⋯ The LMA-ProSeal™ and LMA-Classic™ size 1.5 and 2 provide similar mean airway sealing pressures as assessed by the manometric stability test under standardized conditions, with similar air leak and optimal positioning.