Paediatric anaesthesia
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Paediatric anaesthesia · Nov 2018
Randomized Controlled TrialA randomized controlled trial of oral chloral hydrate vs intranasal dexmedetomidine plus buccal midazolam for auditory brainstem response testing in children.
Moderate to deep sedation is required for an auditory brainstem response test when high-intensity stimulation is used. Chloral hydrate is the most commonly used sedative, whereas intranasal dexmedetomidine is increasingly used in pediatric non-painful procedural sedations. ⋯ Intranasal dexmedetomidine plus buccal midazolam was associated with higher sedation success with deeper level of sedation, with similar discharge time and adverse event rate when compared to chloral hydrate.
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Paediatric anaesthesia · Nov 2018
Randomized Controlled TrialDetermination of the minimal alveolar concentration of sevoflurane associated with isoelectric electroencephalogram in children: A prospective, randomized, double-blind study.
We investigated the minimal alveolar concentration (MAC) of sevoflurane associated with the occurrence of isoelectric electroencephalogram in 50% of children under steady-state conditions (MAC IE). The MAC IE was determined in 100% oxygen and with the addition of 50% nitrous oxide or after the injection of fentanyl. ⋯ The MAC IE of sevoflurane calculated in 100% O2 was 5.30% in children. Addition of 50% N2 O modestly increased MAC IE of sevoflurane, while 3 μg/kg fentanyl had no effect on MAC IE of sevoflurane.