Paediatric anaesthesia
-
Paediatric anaesthesia · Dec 2021
Anesthesiologist-Related Factors Associated with Risk-Adjusted Pediatric Anesthesia-Related Cardiopulmonary Arrest: A Retrospective Two Level Analysis.
Pediatric anesthesia-related cardiac arrest is an uncommon but catastrophic adverse event which has been, in a previous study, associated with anesthesiologist-related factors such as number of days per year providing pediatric anesthesia. We aimed to replicate this and assess other anesthesiologist-related risk factors for anesthesia-related cardiac arrest after adjusting for known underlying risk factors present in the case mix. ⋯ Case mix explained all associations between higher risk of pediatric anesthesia-related cardiac arrest and anesthesiologist-related variables at our institution.
-
Paediatric anaesthesia · Dec 2021
Population pharmacokinetics of oxycodone: Premature neonates to adults.
Oxycodone is used in children and adults for the control of acute postoperative pain. Covariate influences such as age, size, and fat mass on oxycodone pharmacokinetic parameters over the human lifespan are poorly quantified. ⋯ Clearance matured with age; 8% of the typical adult value at 24 weeks postmenstrual age, 33% in a term neonate and reached 90% of the adult clearance value by the end of the first year of life. Allometric scaling using total body weight was the better size descriptor of oxycodone clearance than fat-free mass.