Paediatric anaesthesia
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Paediatric anaesthesia · Oct 2022
Randomized Controlled TrialIntravenous ondansetron reduced nausea but not pruritus following intrathecal morphine in children: interim results of a randomized, double-blinded placebo-control trial.
This study's purpose was to determine if ondansetron can prevent pruritus after administration of intrathecal morphine in children, as has been demonstrated in adults. ⋯ This study found no evidence for intravenous ondansetron as an effective preventative for pruritus following intrathecal morphine in children. However, this RCT did find that the rate of pruritus following intrathecal morphine administration may be significantly higher than previously thought. Nausea and vomiting (a secondary outcome) were reduced significantly in the treatment group. The negative findings of this study reinforce the potential dangers of extrapolating the drug effects seen in adults onto pediatric patients.
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Paediatric anaesthesia · Oct 2022
Randomized Controlled TrialInvasive and non-invasive assessment of macro- and microcirculatory effects of vasopressors during sevoflurane anesthesia in a pediatric experimental model: a randomized trial.
While non-invasive assessment of macro- and micro-circulation has the promise to optimize anesthesia management, evidence is lacking for the relationship between invasive and non-invasive measurements of cardiac output and microcirculatory indices. ⋯ The results of this study suggest that non-invasive cardiac output measurements may not accurately reflect changes in macrocirculation after hemodynamic optimization by vasopressors. Due to the incoherence between macro- and micro-circulation, monitoring microcirculation is essential to guide patient management.