Paediatric anaesthesia
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Paediatric anaesthesia · Apr 2023
Needleless inhaled anesthesia with sevoflurane: advantages of a simplified approach for children with spinal muscular atrophy undergoing intrathecal administration of nusinersen.
Intrathecal nusinersen administration, a fundamental step in the treatment of spinal muscular atrophy, is challenging in children. ⋯ In this single-center experience, needleless general anesthesia with inhaled sevoflurane without imaging guidance has been shown to be feasible for children with spinal muscular atrophy undergoing lumbar puncture for nusinersen administration.
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Paediatric anaesthesia · Apr 2023
Pharmacokinetics of dexmedetomidine in pediatric patients undergoing cardiac surgery with cardiopulmonary bypass.
Cardiopulmonary bypass can affect the pharmacokinetics of anesthetic agents. ⋯ When cardiopulmonary bypass is applied, the plasma concentration of dexmedetomidine decreases due to an increase in the volume of distribution, so a loading dose is required to maintain the previous concentration.