Paediatric anaesthesia
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Paediatric anaesthesia · Apr 2023
Needleless inhaled anesthesia with sevoflurane: advantages of a simplified approach for children with spinal muscular atrophy undergoing intrathecal administration of nusinersen.
Intrathecal nusinersen administration, a fundamental step in the treatment of spinal muscular atrophy, is challenging in children. ⋯ In this single-center experience, needleless general anesthesia with inhaled sevoflurane without imaging guidance has been shown to be feasible for children with spinal muscular atrophy undergoing lumbar puncture for nusinersen administration.
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Paediatric anaesthesia · Apr 2023
Pharmacokinetics of dexmedetomidine in pediatric patients undergoing cardiac surgery with cardiopulmonary bypass.
Cardiopulmonary bypass can affect the pharmacokinetics of anesthetic agents. ⋯ When cardiopulmonary bypass is applied, the plasma concentration of dexmedetomidine decreases due to an increase in the volume of distribution, so a loading dose is required to maintain the previous concentration.
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Paediatric anaesthesia · Apr 2023
Ketamine-Dexmedetomidine combination (KETODEX) for sedation in pediatric major surgery in a low-income country.
Anorectal malformations are one of the most frequent congenital malformations treated by pediatric surgeons. In low-income countries, the surgical and anesthetic management of children in need of these procedures can be challenging. ⋯ We present a series of four cases of anorectal malformations corrections in Guinea Bissau, in children up to 13 months of age, under regional anesthesia and sedation with ketodex, a mixture of ketamine and dexmedetomidine (in a proportion of 1 mg to 1 μg). No child developed respiratory depression requiring airway intervention or supplemental oxygen, or had hemodynamic instability.
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Paediatric anaesthesia · Apr 2023
Childhood Obesity Trends: Association with Same-Day Hospital Admission in a National Outpatient Surgical Population.
Although the prevalence of obesity in the general population and its perioperative implications among children undergoing inpatient surgeries are well known, little is known about obesity prevalence among children scheduled for ambulatory surgery. ⋯ The burden of obesity continues to increase in children scheduled for ambulatory surgery. Children with class 2 and class 3 obesity have higher rates of same-day hospital admission following elective ambulatory surgery compared to healthy weight children, a factor that should be considered in scheduling these patients.