Paediatric anaesthesia
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Safe effective analgesia for neonates undergoing major surgery remains a challenge particularly in institutions where resources are limited. The experience in the use of epidural analgesia in 240 neonates weighing between 0.9-5.8 kg body weight (lumbar n = 211, thoracic n = 29) is reviewed. Dural puncture (n = 1), convulsion (n = 1) and intravascular migration of catheter (n = 1) were the only complications. ⋯ Skin epidural distance ranged between 3 and 12 mm (mean 6.0 +/- 1.7 mm) and did not correlate with the patients' weight. Patients remained haemodynamically stable except occasional bradycardia below 100 (n = 15) which was successfully managed with anticholinergics. The potential risks and benefits of epidural analgesia in this age group are discussed and arguments for intermittent 'top-up' doses rather than continuous infusions presented.
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Paediatric anaesthesia · Jan 1998
Respiratory function in children during recovery from neuromuscular blockade.
Residual neuromuscular blockade is a major risk factor for respiratory insufficiency. We examined the relationship between neuromuscular and respiratory function in 18 ASA I or II children aged 2-4 years. Lung function was measured by pneumotachography and transpulmonary pressure, neuromuscular transmission by first twitch response ratio (T1:T1) and train-of-four ratio (TOFR), before and at specific points in recovery from vecuronium paralysis. ⋯ The best predictors of minute ventilation were the P0.1 (r = 0.57), and the TOFR (r = 0.62). PIOCC and P0.1 correlated closely (r = 0.889, P = 0.002) but TOFR and T1:T1 did not correlate with either. Our results show that the occlusion pressure measurements, P0.1 and PIOCC, were good predictors of both VE.kg-1 and respiratory work.
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Paediatric anaesthesia · Jan 1998
Sevoflurane for controlled hypotension during spinal surgery: preliminary experience in five adolescents.
The physical properties of sevoflurane suggest that it may be a suitable agent for controlled hypotension. With its low blood:gas partition coefficient of 0.69, it has a rapid onset of action making it easy to rapidly control blood pressure. The current report outlines preliminary experience with sevoflurane for controlled hypotension during posterior spinal fusion in five adolescents. ⋯ No patient required calcium, alpha adrenergic agonists, or ephedrine for excessive hypotension. When controlled hypotension was no longer necessary, the sevoflurane concentration was decreased to 1%. After decreasing the sevoflurane to 1%, the time to return of the MAP to baseline varied from 4 to 8 min (5.6 +/- 1.8 min).