Paediatric anaesthesia
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Paediatr Anaesth
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Paediatric anaesthesia · Apr 2022
ReviewAnesthesia and neurotoxicity study design, execution, and reporting in the nonhuman primate: A systematic review.
Concern for a role of anesthesia in neurotoxicity in children originated from neonatal rodent and nonhuman primate (NHP) models, yet prospective clinical studies have largely not supported this concern. The goal of this study was to conduct an objective assessment of published NHP study rigor in design, execution, and reporting. ⋯ Important deficits in study design, execution, and reporting were identified in neonatal NHP studies. These results raise concern for the validity and reliability of these studies and may explain in part the divergence from results obtained in human neonates.