Paediatric anaesthesia
The most recent articles from:
Paediatr Anaesth
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Paediatric anaesthesia · Nov 2017
Pharmacokinetics of S-ketamine during prolonged sedation at the pediatric intensive care unit.
S-ketamine is the S(+)-enantiomer of the racemic mixture ketamine, an anesthetic drug providing both sedation and analgesia. In clinical practice, significant interpatient variability in drug effect of S-ketamine is observed during long-term sedation. ⋯ Substantial interpatient variability in pharmacokinetics in children complicates the development of adequate dosage regimen for continuous sedation.