Paediatric anaesthesia
-
Paediatric anaesthesia · Mar 2017
ReviewSequential allocation trial design in anesthesia: an introduction to methods, modeling, and clinical applications.
Estimation of the dose-response curve for new anesthetic protocols typically focuses on identifying minimum effective doses. The application of a sequential experimental method is appropriate, as it minimizes sample size requirements by updating dose assignments based on information accrued from successive subjects. One approach is the up-and-down method for estimating the median effective dose in a patient population (ED50 ). ⋯ In conclusion the up-and-down method can be more efficient than nonsequential designs for the estimation of the median dose/intervention level for a given intervention (ED50 ). The biased coin approach or continual reassessment method are preferred for the estimation of higher or lower tail quantiles such as ED90 or ED10. Continual reassessment method may be superior if knowledge of the dose-response relationship is available for the drug of interest.
-
Paediatric anaesthesia · Mar 2017
Congenital diaphragmatic hernia: outcomes of neonates treated at Mayo Clinic with and without extracorporeal membrane oxygenation.
Congenital diaphragmatic hernia (CDH) is a rare anomaly with high mortality and long-term comorbid conditions. ⋯ The overall survival of neonates with CDH was 79%. Intrathoracic liver herniation was associated with more frequent use of ECMO and greater mortality. A substantial number of survivors, especially those who required ECMO, experienced chronic conditions after discharge.
-
Paediatric anaesthesia · Mar 2017
Comment LetterReply to Nielsen, Dominic; Visram, Anil, regarding their comment 'Comment on Tait AR, Bickham R, O'Brien LM, Quinlan M, Voepel-Lewis T. The STBUR questionnaire for identifying children at risk for sleep-disordered breathing and postoperative opioid-related adverse events - potential confounders'.