Paediatric anaesthesia
The most recent articles from:
Paediatr Anaesth
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Paediatric anaesthesia · Dec 2016
Randomized Controlled TrialPharmacokinetics and analgesic effectiveness of intravenous parecoxib for tonsillectomy ± adenoidectomy.
Few pharmacokinetic (PK) and pharmacodynamic (PD) data exist for COX-2 selective inhibitors in children. We wished to characterize the PKPD of parecoxib and its active metabolite, valdecoxib, in this population. ⋯ Parecoxib 0.9 mg·kg(-1) in a 2-year-old, 0.75 mg·kg(-1) in a 7-year-old, and 0.65 mg·kg(-1) in a 12-year-old child achieves dose equivalence of 40 mg in a standard 70 kg person. Clearance maturation may occur in infants younger than the current cohort. Parecoxib doses above 1 mg·kg(-1) add no additional analgesia.