Paediatric anaesthesia
The most recent articles from:
Paediatr Anaesth
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Paediatric anaesthesia · Aug 2008
Randomized Controlled TrialDexmedetomidine disposition in children: a population analysis.
There are few data describing dexmedetomidine population pharmacokinetics (PK) in children (0-15 years) despite increasing use. ⋯ Clearance in neonates is approximately one-third of that described in adults, consistent with immature elimination pathways. Maintenance dosing, which is a function of clearance, should be reduced in neonates and infants when using a target concentration approach.