Medicina intensiva
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The series of updates on methodology for research in critically ill patients has addressed the difficulties caused by the characteristics of patients of this kind, bioethics, the interpretation of results, and methodological error. New statistical methods for causality research, meta-analysis and big data analysis have also been described. ⋯ We close the series with the hope of having provided a global vision of the statistical methods oriented toward the future, with the aim of promoting statistical culture. In parallel, we have analyzed the evolution in complexity of the methodological analysis in the journal.
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Antiseptics are chemical substances that when applied topically onto intact skin, mucous membranes or wounds partially or completely reduces the population of living microorganisms in those tissues. Different types of antiseptics are available - those most commonly used in clinical practice being alcohols, iodinated compounds and chlorhexidine. When using an antiseptic, consideration is required of its spectrum of antimicrobial activity, latency, residual effects, possible interferences of the presence of organic material with the activity of the antiseptic, its side effects, compatibility with other antiseptics, and cost. This article is part of a supplement entitled "Antisepsis in the critical patient", which is sponsored by Becton Dickinson.